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Effects of Propranolol on Bone Metabolism in Spontaneously Hypertensive Rats

Effects of Propranolol on Bone Metabolism in Spontaneously Hypertensive Rats,10.1124/jpet.110.167643,Journal of Pharmacology and Experimental Therapeu

Effects of Propranolol on Bone Metabolism in Spontaneously Hypertensive Rats   (Citations: 1)
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    • ...Sato et al. [28]. Rat (SHR/Izm and WKY/Izm, #,...
    • ...Similarly, bone loss in spontaneously hypertensive rats (SHR) was well prevented by the lowest oral treatment dose (1 mg/kg) whereas the two higher dose (50 and 100 mg/kg) had no protective effects [28]...
    • ...In the same study [28], a different scale of dose‐response experimentation was also included—0.1, 1, and 10 mg/kg by oral gavage...
    • ...Thus, although different animal models were used, our study and the two previous studies [26, 27] all used a relatively higher oral dose of propranolol than the effective doses for SHR used by Sato et al. [28]...

    Tsang-Hai Huanget al. The effects of systemic chemical sympathectomy on local bone loss indu...

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