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Cloned Glutamate Receptors

Cloned Glutamate Receptors,10.1146/annurev.ne.17.030194.000335,Annual Review of Neuroscience,Michael Hollmann,Stephen Heinemann

Cloned Glutamate Receptors   (Citations: 1650)
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Journal: Annual Review of Neuroscience - ANNU REV NEUROSCI , vol. 17, no. 1, pp. 31-108, 1994
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    • ...KA1 and KA2 along with GluR5 and GIuR6 form different combinations together, but KA1 and KA2 expressed in the host cell do not form a functional ion channel [19]...

    Sheng PengYanet al. Glutamate receptors and signal transduction in learning and memory

    • ...J. Tosi, et al.: Retinal Ganglion Cells Imaging in Live Mouse Models of Glaucoma 391 aspartic acid) and KA (Kainate) [27, 28]...

    Joaquin Tosiet al. Rapid and Noninvasive Imaging of Retinal Ganglion Cells in Live Mouse ...

    • ...Four subunits, GluA1‐A4 (GluR1‐4 or GluR-A to -D) (Collingridge et al.,2008),contribute totheformation ofheterotetrameric receptors (Dingledine et al., 1999; Hollmann and Heinemann, 1994; Mayer and Armstrong, 2004; Seeburg, 1993)...
    • ...It has long been known that edited GluA2 subunits, unlike other subunits, produce very small currents as homomeric channels in heterologous expression systems (Burnashev et al., 1992; Hollmann and Heinemann, 1994)...

    Wei Luet al. Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Ce...

    • ...Excitatory synaptic transmission in brain is primarily mediated by theneurotransmitterglutamate.Glutamatereleasedfrompresynaptic terminals binds to three classes of ionotropic glutamate receptors, which are pharmacologically classified as AMPA- (amino-3-hydroxy-5-methylisoxazole-4-propionic acid), NMDA- (N-methyl-D-aspartic acid), and kainate-sensitive glutamate receptors (Dingledine et al., 1999; Hollmann and Heinemann, 1994; Seeburg, ...

    Wei Zhanget al. A Transmembrane Accessory Subunit that Modulates Kainate-Type Glutamat...

    • ...Glutamate is the most abundant excitatory neurotransmitter in the brain and acts on three classes of ionotropic glutamate receptors (AMPA, NMDA, and kainate), which function distinctly (Dingledine et al., 1999; Hollmann and Heinemann, 1994; Seeburg, 1993)...
    • ...AMPA receptors are hetero-oligomers composed of four subunits, GluR1-4 (Hollmann and Heinemann, 1994; Seeburg, 1993), each of which is alternatively spliced to yield two isoforms (flip and flop) (Sommer et al., 1990)...
    • ...Furthermore, glutamate-evoked steady-state current from cells expressing recombinant AMPA receptors have typical sigmoid concentrationresponse curves (Hollmann and Heinemann, 1994; Robert and...

    Megumi Morimoto-Tomitaet al. Autoinactivation of Neuronal AMPA Receptors via Glutamate-Regulated TA...

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