Effects of Unilateral Motor Cortex Lesion on Ipsilesional Hand's Reach and Grasp Performance in Monkeys: Relationship With Recovery in the Contralesional Hand

...Furthermore, depending on the time separating the lesion from the observation, often several weeks, months or years post-lesion, a re-organization of the motor system may have significantly modified or adapted the performance of the ipsilesional hand, as compared to the prelesion performance (e.g. Kaeser et al. 2010)...
...Postlesion, the behavioral tasks were pursued during several months (see Kaeser et al. 2010, for long-term effects)...
...Rouiller et al. 1998; Liu and Rouiller 1999; Schmidlin et al. 2004; Freund et al. 2006, 2009; Kaeser et al. 2010, 2011): briefly, the tests were performed on a perspex board (10 cm 9 20 cm) containing 50 randomly distributed slots, each filled with a food pellet at the beginning of the test...
...horizontal slots targeted by the monkey in a given daily session (Kaeser et al. 2010)...
...The surgical goal was to restrict the unilateral lesion mainly to the hand representation in M1. To do so, ICMS sessions were performed to map M1: a tungsten microelectrode (0.1‐1 MX impedance, FHC Inc, USA) was used to micro-stimulate M1, along penetrations at 1 mm from each other, as previously described in detail (Schmidlin et al. 2004, 2005; Kaeser et al. 2010)...
...The ICMS map was finally represented in the form of an unfolded map of M1, as previously reported (Park et al. 2001, 2004; Kaeser et al. 2010) and provided the basis with which to guide injections of ibotenic acid in order to produce a lesion of M1 centered on the hand area...
...The number of ICMS sites injected and the total volume of ibotenic acid infused in M1 are indicated for each monkey in Table 1. Several minutes after the ibotenic acid infusion, the contralateral hand exhibited a dramatic paralysis (see Liu and Rouiller 1999; Kaeser et al. 2010, 2011)...
...V appeared somewhat less densely packed (contrasting with the SMI-32 positive neurons which completely disappeared in the lesion territory in the other 11 monkeys; see Kaeser et al. 2010)...
...extrapolated from the reconstructions of the lesion on consecutive histological sections of the brain (see Table 1; Kaeser et al. 2010)...
...Unilateral lesion of the motor cortex was produced by infusion of ibotenic acid at multiple sites defined by ICMS (see Kaeser et al. 2010)...
...The method to unfold the rostral bank of the central sulcus has been described previously (Kaeser et al. 2010)...
... there is no obvious correlation with the size and/or the precise position of the lesion (Fig. 1). Moreover, deficits in the ipsilesional hand’s manual performance during the days following the lesion of M1 did not correlate with the presence or absence of enhancement of manual performance of the ipsilesional hand on the long-term, found in the monkeys which recovered best their manual performance for the contralesional hand (Kaeser et al. ...

Shahid Bashir, et al. Short-term effects of unilateral lesion of the primary motor cortex (M...

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Shahid Bashir, et al. Short-term effects of unilateral lesion of the primary motor cortex (M...

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Stability analysis and design of switched normal systems (Citations: 9)

Short-term effects of unilateral lesion of the primary motor cortex (M1) on ipsilesional hand dexterity in adult macaque monkeys


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