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Transient Disabling Dyskinesias: A Predictor of Good Outcome in Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease

Transient Disabling Dyskinesias: A Predictor of Good Outcome in Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease,10.1159/000177941,Eu

Transient Disabling Dyskinesias: A Predictor of Good Outcome in Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease   (Citations: 2)
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We report 5 of 75 (6.6%) patients with Parkinson’s disease (PD) submitted to subthalamic nucleus deep brain stimulation (STN-DBS) who developed transient disabling dyskinesias immediately after surgery. Dyskinesias persisted despite levodopa withdrawal, cessation or reduction of stimulation, and resolved spontaneously in a maximum period of 12 weeks without the need to change stimulation active contact. Compared to the rest of our PD patients submitted to STN-DBS, the dyskinesia group needed a lower levodopa-equivalent daily dosage (LEDD) over the time of follow-up. A microlesion in the STN, probably concealed in cerebral MRI by the electrode-related artifact, could have been involved in the etiopathology of our patients’ symptoms. The presence of transient disabling dyskinesia in PD patients immediately after STN-DBS might be a predictor of good outcome as measured by a decrease in the LEDD needed.
Journal: European Neurology - EUR NEUROL , vol. 61, no. 2, pp. 94-99, 2009
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