Academic
Publications
Neuropsychiatric Manifestations in Mild Cognitive Impairment: A Systematic Review of the Literature

Neuropsychiatric Manifestations in Mild Cognitive Impairment: A Systematic Review of the Literature,10.1159/000112509,Dementia and Geriatric Cognitive

Neuropsychiatric Manifestations in Mild Cognitive Impairment: A Systematic Review of the Literature   (Citations: 35)
BibTex | RIS | RefWorks Download
Background: Mild cognitive impairment (MCI) is an etiologically heterogeneous condition that is characterized by cognitive changes without impairment of activities of daily living and insufficient to represent dementia. MCI is an important risk state for dementia. Neuropsychiatric symptoms may be present in MCI. Methods: We executed a PubMed search for articles on the neuropsychiatric manifestations in MCI and reviewed their findings. Results: Behavioral abnormalities are reported in 35–75% of MCI patients with the most common being depression, apathy, anxiety and irritability. The observed variability in symptom prevalence can be explained by the different sampling methods, MCI diagnostic criteria and behavioral instruments used. There is a compelling body of evidence that MCI patients with behavioral features are more prone to develop Alzheimer’s disease (AD) than patients without these features. Conclusions: Neuropsychiatric symptoms are common features of MCI. The behavioral changes observed in MCI are similar to those of AD and may help identify the subgroup of MCI patients with prodromal AD. Large prospective longitudinal studies would greatly contribute to our understanding of the epidemiology, diagnostic and prognostic value of the neuropsychiatric features in MCI.
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
    • ... A recent review also suggested that MCI is associated with neuropsychiatric symptoms, cited as being of potential importance for defining subgroups at higher risk of developing dementia in the future ...

    Ana Luisa Sosaet al. Prevalence, Distribution, and Impact of Mild Cognitive Impairment in L...

    • ... Furthermore, individuals with amnestic mild cognitive impairment (MCI) with depressive symptoms show increased propensity for Alzheimer's disease (AD), especially when they are also depressed (...

    Hyun Kook Limet al. Regional Cortical Thickness and Subcortical Volume Changes Are Associa...

    • ...MCI patients with behavioral changes have an increased risk of progression to Alzheimer’s disease (AD) compared to patients without these symptoms [...

    Magda Tsolakiet al. Effectiveness of Nonpharmacological Approaches in Patients with Mild C...

    • ... 0.586 Male gender, n (%) 241 (49) 10 (40) 0.386 236 (49) 15 (44) 0.601 Ischemic heart disease, n (%) 14 (3) 1 (4) 0.736 14 (3) 1 (3) 0.987 Hypertension, n (%) 171 (35) 11 (44) 0.341 168 (35) 14 (41) 0.445 Diabetes mellitus, n (%) 48 (10) 2 (8) 0.774 47 (10) 3 (9) 0.866 Hyperlipidemia, n (%) 249 (51) 12 (48) 0.807 247 (51) 14 (41) 0.267 Smoking, n (%) 89 (18) 6 (24) 0.453 87 (18) 8 (24) 0.419 Family history of stroke, n (%) 141 (29) 6 (24) ...
    • ... n (%) 241 (49) 10 (40) 0.386 236 (49) 15 (44) 0.601 Ischemic heart disease, n (%) 14 (3) 1 (4) 0.736 14 (3) 1 (3) 0.987 Hypertension, n (%) 171 (35) 11 (44) 0.341 168 (35) 14 (41) 0.445 Diabetes mellitus, n (%) 48 (10) 2 (8) 0.774 47 (10) 3 (9) 0.866 Hyperlipidemia, n (%) 249 (51) 12 (48) 0.807 247 (51) 14 (41) 0.267 Smoking, n (%) 89 (18) 6 (24) 0.453 87 (18) 8 (24) 0.419 Family history of stroke, n (%) 141 (29) 6 (24) 0.619 138 (29) 9 ...

    Yusuke Yakushijiet al. Brain Microbleeds and Global Cognitive Function in Adults Without Neur...

    • ...prevalence of behavioural and psychological symptoms in those with mild cognitive impairment (MCI) and suggested that differences in the settings of studies, the characteristics of participant groups, and the definitions of symptoms and of MCI contribute to this variation [6,7]...
    • ...Recent reviews have demonstrated large variation in estimates of the prevalence of behavioural and psychological symptoms in MCI [6,7]...
    • ...Several studies in patients with MCI have shown that those with behavioural and psychological symptoms have an increased risk of dementia incidence and suggest that noncognitive symptoms should be a consideration when identifying those in the earliest stages of dementia [6,7]...

    Rianne van der Lindeet al. Behavioural and psychological symptoms in the older population without...

Sort by: