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Isolation and Characterization of a Population of Immature Dental Pulp Stem Cells Expressing OCT-4 and Other Embryonic Stem Cell Markers

Isolation and Characterization of a Population of Immature Dental Pulp Stem Cells Expressing OCT-4 and Other Embryonic Stem Cell Markers,10.1159/00009

Isolation and Characterization of a Population of Immature Dental Pulp Stem Cells Expressing OCT-4 and Other Embryonic Stem Cell Markers   (Citations: 41)
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We report the isolation of a population of immature dental pulp stem cells (IDPSC), which express embryonic stem cell markers Oct-4, Nanog, SSEA-3, SSEA-4, TRA-1-60 and TRA-1-81 as well as several other mesenchymal stem cell markers during at least 25 passages while maintaining the normal karyotype and the rate of expansion characteristic of stem cells. The expression of these markers was maintained in subclones obtained from these cells. Moreover, in vitrothese cells can be induced to undergo uniform differentiation into smooth and skeletal muscles, neurons, cartilage, and bone under chemically defined culture conditions. After in vivo transplantation of these cells into immunocompromised mice, they showed dense engraftment in various tissues. The relative ease of recovery and the expression profiles of various markers justify further exploration of IDPSC for clinical therapy.
Journal: Cells Tissues Organs , vol. 184, no. 3-4, pp. 105-116, 2006
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    • ...OCT4A confers the stemness properties of ES cells and is critically involved in the self-renewal of undifferentiated ES cells, whereas the function of OCT4B is unknown (Scholer et al., 1989; Kerkis et al., 2006; Medvedev et al., 2008)...

    Jian-jun Renet al. A relative quantitative method to detect OCT4A gene expression by exon...

    • ...Stem cells from human exfoliated deciduous teeth (SHED) ++++++++ Dentinogenic, osteogenic, adipogenic, neurogenic, chondrogenic, myogenic [47, 76, 77]...
    • ...Adult stem cells of dental origin such as dental pulp stem cells (DPSC) [72–75], stem cells from human exfoliated deciduous teeth (SHED) [76, 77], stem cells from apical papilla (SCAP) [78, 79], dental follicle progenitor cells (DFPC) [80, 81], and periodontal ligament stem cells (PDLSC) [82–85] have been analyzed on the basis of proliferative potential and differentiation capacity to osteogenic, cementogenic, and neurogenic lineages, and ...

    Bülend Inançet al. Stem Cells in Tooth Tissue Regeneration—Challenges and Limitations

    • ...In this context, two points are of interest: (1) CD146 was detected on almost all kinds of undifferentiated dental cells and (2) CD13 was expressed on embryonic-like dental pulp stem cells [16]...

    Christian Morsczecket al. Comparison of human dental follicle cells (DFCs) and stem cells from h...

    • ...Recent studies have shown that adult stem cells, including MSCs, may express ESC markers: SSEA-4 expression has been detected in bone marrow [17, 18] and dental pulp stem cells [6]; Oct4 expression has been reported in bone marrow [18, 19] and adipose tissuederived stem cells [20], peripheral blood mononuclear cells [21], dental pulp stem cells [6], heart and liver cells [7]; Nanog expression has been found in bone marrow, heart and liver ...
    • ...Recent studies have shown that adult stem cells, including MSCs, may express ESC markers: SSEA-4 expression has been detected in bone marrow [17, 18] and dental pulp stem cells [6]; Oct4 expression has been reported in bone marrow [18, 19] and adipose tissuederived stem cells [20], peripheral blood mononuclear cells [21], dental pulp stem cells [6], heart and liver cells [7]; Nanog expression has been found in bone marrow, heart and liver ...

    Una Riekstinaet al. Embryonic Stem Cell Marker Expression Pattern in Human Mesenchymal Ste...

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