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Tetrandrine Inhibits Proinflammatory Cytokines, iNOS and COX2 Expression in Human Monocytic Cells

Tetrandrine Inhibits Proinflammatory Cytokines, iNOS and COX2 Expression in Human Monocytic Cells,10.1248/bpb.30.59,Biological & Pharmaceutical Bullet

Tetrandrine Inhibits Proinflammatory Cytokines, iNOS and COX2 Expression in Human Monocytic Cells   (Citations: 11)
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Journal: Biological & Pharmaceutical Bulletin - BIOL PHARM BULL , vol. 30, no. 1, pp. 59-62, 2007
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    • ...It is also unclear whether the enhancement of immune response at this stage, if any, may play a role in the inhibition of macrophage transformation into epithelioid cells following injury. This may account for the anti-inflammatory activities produced by MSM in both the acute and chronic models of inflammation employed. Even though the exact mechanism of action is unknown, the anti-inflammatory activity of M. speciosa may result from a combination of inhibition of pro-inflammatory mediator release and vascular permeability in addition to enhanced immunity, stimulation of tissue repair and healing processes. Furthermore, phytochemical analysis of MSM has demonstrated the presence of alkaloids, saponins, flavonoids, tannins and sterols. The anti-inflammatory and/or antinociceptive actions of these compounds have been reported by many researchers. Moreover, the suppression of inducible nitric oxide synthase and cyclo-oxygenase-2 enzymes has been shown for alkaloids and flavonoids [...

    W. M. Shaik Mossadeqet al. Anti-Inflammatory and Antinociceptive Effects of Mitragyna speciosa Ko...

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