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Small-molecule inhibitors of PDE-IV and -VII in the treatment of respiratory diseases and chronic inflammation

Small-molecule inhibitors of PDE-IV and -VII in the treatment of respiratory diseases and chronic inflammation,10.1517/13543784.16.10.1585,Expert Opin

Small-molecule inhibitors of PDE-IV and -VII in the treatment of respiratory diseases and chronic inflammation   (Citations: 7)
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Journal: Expert Opinion on Investigational Drugs - EXPERT OPIN INVESTIG DRUGS , vol. 16, no. 10, pp. 1585-1599, 2007
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    • ...Another interesting approach would be to develop inhibitors of other PDE classes to be used in combination with PDE4 inhibitors, with the goal of maintaining or enhancing efficacy while reducing the dose-limiting side effects associated with these drugs [35]...
    • ...While others have begun to explore the concept that combined or dual PDE4/PDE7 inhibitors may provide a better therapeutic ratio [35], our data support this idea and suggest that such an approach is valuable for potent inhibition of key inflammatory markers...

    Marylène Fortinet al. A multi-target antisense approach against PDE4 and PDE7 reduces smoke-...

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