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Herbal Compounds and Toxins Modulating TRP Channels

Herbal Compounds and Toxins Modulating TRP Channels,10.2174/157015908783769644,Current Neuropharmacology,Rudi Vennekens,Joris Vriens,Bernd Nilius

Herbal Compounds and Toxins Modulating TRP Channels   (Citations: 9)
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Journal: Current Neuropharmacology - CURR NEUROPHARMACOL , vol. 6, no. 1, pp. 79-96, 2008
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    • ...Zingerone is one of the pungent components of ginger, which is included in up to 3% of essential oil with gingerol and shogaol [8]...
    • ...It has been shown that some of pungent compounds can activate sensory nerves expressing TRPV1 in the gut [8, 17, 18]...
    • ...Zingerone exerts its inhibitory effect on colonic motility at concentrations above 10 mM. Considering that capsaicin is usually used at submicromolar concentrations [8, 28], the concentrations of zingerone seem to be rather high from a pharmacological point of view...
    • ...However, the concentrations used in the present study would be reasonable, because zingerone is a much less potent analog of capsaicin [8, 19, 29]...

    Momoe Iwamiet al. Inhibitory effects of zingerone, a pungent component of Zingiber offic...

    • ...TRPV1 is a non-selective cation channel with a preference for calcium, which can be directly activated by noxious heat (> 43°C), extracellular acidification, as well as a large heterogeneous group of natural compounds such as dihydrocapsaicin (DHC) from chili pepper [3,4]...

    Keld Fosgerauet al. Increased susceptibility to cardiovascular effects of dihydrocapcaicin...

    • ...The TRPV1 receptor is a target for a large heterogeneous group of natural compounds including capsaicinoids such as capsaicin and dihydrocapsaicin (DHC) from chili pepper, piperine from black pepper, resiniferatoxin (RTX), ginsenosides, evodiamine and others that acts as agonists [20]...

    Keld Fosgerauet al. Drug-induced mild therapeutic hypothermia obtained by administration o...

    • ... Many members of this family are activated by chemical substances that often come from plant...

    Thomas F. J. Wagneret al. Transient receptor potential M3 channels are ionotropic steroid recept...

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