Influence of integrin-binding motif (RGD) on the attachment and internalization of avian adenovirus CELO in mammalian cells
Recombinant avian adenovirus CELO bearing sequence RGD in the structure of a long-fiber HI loop was designed. Experiments
in vitro revealed that the introduction of an RGD motif into the fiber of CELO increased the ability of the virus to be attached
to a surface of CAR-negative cells, and raised the efficiency of the process of internalization of the virus both in CAR-positive
and in CAR-negative cells.