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Liposomes coupled with monoclonal antibodies against glioma-associated antigen for targeting chemotherapy of glioma

Liposomes coupled with monoclonal antibodies against glioma-associated antigen for targeting chemotherapy of glioma,10.3171/jns.1989.71.3.0382,Journal

Liposomes coupled with monoclonal antibodies against glioma-associated antigen for targeting chemotherapy of glioma   (Citations: 4)
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Journal: Journal of Neurosurgery - JNS , vol. 71, no. 3, pp. 382-387, 1989
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    • ...As to cell or tissue targeting, Kito et al. [2] investigated the targeting of liposomes to specific cells by using appropriate cytophilic ligands such as monoclonal antibody and indicated that brain tumorassociated monoclonal antibody-coupled liposomes containing methotrexate (MTX) have selective cytotoxicity towards glioma cells and could be utilized for targeting the chemotherapy of gliomas...

    Jun Yoshidaet al. Clinical Gene Therapy for Brain Tumors. Liposomal Delivery of Anticanc...

    • ...For this purpose, we examined novel lipo somes, which were recently developed by us (10), as vehicles for such transfection. Since our previous work (11) demon-...
    • ...In this case, however, no in crease in HuIFN-/3 level was observed when the antibodycoupled liposomes were used, indicating that the coupling of the antibody to liposomes produces no effect on the incorpo ration of the content of liposomes into cells if specific antigen/ antibody interaction does not occur, as was already observed with antibody-coupled liposomes containing drugs (11)...
    • ...cells and lead to a significant increase in the uptake of liposomal content by the cells (11)...

    Masaaki Mizunoet al. Growth Inhibition of Glioma Cells Transfected with the Human ß-Interf...

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