Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

...The adverse outcome pathway concept has been recently introduced in eco-toxicology as a method for a more intelligent approach to risk assessment testing 6,28...

...This measurement represents a baseline for toxicity, as discussed in Ankley et al. (2010)...

...Ideally, the integration of “omics” data with traditional ecotoxicological parameters will elucidate mechanistic networks that can be used to incorporate biomarkers in predictive quantitative models of adverse outcome pathways [5,6]...
...It is suggested that molecular biomarkers based on gene induction, in combination with conventional endpoints, can provide robust insight of the dose responses and mechanistic underlying effects of unknown chemical compounds [6]...
...Differences in SSH libraries between cadmium and phenanthrene Gene expression changes following exposure to chemically spiked media often point to the molecular mechanisms that are used to cope with hazardous substances [6]...
...This is believed to be the result of reversible and non-specific disturbance of membrane integrity and function resulting from the partitioning of the chemical into biological membranes [6,54]...

... Current focus is on the development of screening tools to assess the ecosystem quality based on the integration of several endpoints at the molecular, cellular and population levels ...

...Notable progress is being made on the development and use of toxicity pathway models and the creation of prioritization schemes, toxicology knowledgebases, and systems biology models in the field of environmental science (Schmieder et al, 2004; Degitz et al, 2005; Ankley et al, 2009)...

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