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Visualizing Chromatin Dynamics in Interphase Nuclei

Visualizing Chromatin Dynamics in Interphase Nuclei,10.1126/science.1067703,Science,S. M. Gasser

Visualizing Chromatin Dynamics in Interphase Nuclei   (Citations: 118)
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Journal: Science , vol. 296, no. 5572, pp. 1412-1416, 2002
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    • ... There is increasing evidence that the positioning of genomic regions in the nuclear space is important for gene regulation ...

    Hisakatsu Nawataet al. Dysregulation of Gene Expression in the Artificial Human Trisomy Cells...

    • ...Extensively, rapid movements of chromatin were reported for nuclei of budding yeast and Drosophila [21, 22]...

    Chunxiang Liet al. Dynamic changes of territories 17 and 18 during EBV-infection of human...

    • ...What prevents long chromosome fibres of a given chromosome from spreading through the entire volume of the nucleus and from intermingling with chromatin fibres of other chromosomes? To appreciate this question one needs to realize that there are no membranes confining individual chromosome territories and that chromatin fibres are very dynamic (5)...
    • ...Why then should the linear chromosomes behave like non-penetrable circular polymers? Several papers have reported that chromatin fibres are forming large loops closed by interaction with specific proteins (3,31), in addition specific regions of chromosomes such as centromeres and telomeres show attachments to the nuclear membrane (5,32)...
    • ...Once we accept the possibility that normal chromatin fibres hardly serve as substrates for type II DNA topoisomerases, we may consider what would happen if chromosomes were decondensing to long linear chromatin fibres that were free from any loops or attachment points to nuclear membrane [although we know that this is not the case (3,5,31,32)]...

    Julien Dorieret al. Topological origins of chromosomal territories

    • ...Some examples of this diversity are the speed of cell migration [140‐170 µm/h for neural crest cells (Kulesa and Fraser, 2000)], telomere motion in yeast [0.05 µm/sec (Gasser, 2002)], fast calcium waves [10‐50 µm/sec (Jaffe and Créton, 1998)], red blood cell motion in the developing cardio-vascular system of rodents [1‐10 mm/s (Joneset al., 2004)], and the frequency of beating cilia [3‐40 Hz (Sisson et al., 2003)...

    Julien Vermotet al. Fast fluorescence microscopy for imaging the dynamics of embryonic dev...

    • ...In yeast, telomeres and centromeres are tethered at or near the nuclear envelope [22] and reviewed in Gasser [37], with obvious implications for telomere motility...

    Xueying Wanget al. Rapid telomere motions in live human cells analyzed by highly time-res...

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