Academic
Publications
Serotonin facilitates AMPA-type responses in isolated siphon motor neurons of Aplysia in culture

Serotonin facilitates AMPA-type responses in isolated siphon motor neurons of Aplysia in culture,10.1111/j.1469-7793.2001.00501.x,Journal of Physiolog

Serotonin facilitates AMPA-type responses in isolated siphon motor neurons of Aplysia in culture   (Citations: 27)
BibTex | RIS | RefWorks Download
Journal: Journal of Physiology-london - J PHYSIOL-LONDON , vol. 534, no. 2, pp. 501-510, 2001
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
    • ...This is consistent with previous findings that treatment with repeated pulses of 5-HT only enhances glutamate sensitivity on those regions of the postsynaptic target directly opposed to presynaptic SN varicosities but has no effect on isolated MN (Zhu et al., 1997) . By contrast, Chitwood et al. (2001) found that the application of brief pulses of glutamate combined with a 10 min exposure to 5-HT was sufficient to induce an increase in the ...

    Hsiu-Ling Liet al. Dscam Mediates Remodeling of Glutamate Receptors in Aplysia during De ...

    • ...Three forms of sensitization induced by the application of serotonin are distinguished in Aplysia on the basis of the duration of the effect: short-term, lasting 15‐30 min, intermediate, lasting up to 1.5 h, and long-term, lasting more than 1.5 h [22, 23, 25]...

    M. S. Abramovaet al. Effects of protein synthesis inhibitors on the sensitization of a defe...

    • ...Long-term potentiation (LTP) of glutamate (Glu) synapses is considered by many authors as a basis for learning and memory in animals of different species (Milner et al., 1998; Lewin and Walters, 1999; Lu et al., 1999; Chitwood et al., 2001; Antonov etal.,2003;Balabanetal.,2004).Cyclicadenosinemonophosphate(cAMP)andcyclic guanosine monophosphate (cGMP) play an important role in the mechanisms of this potentiation...
    • ...Serotonin (5-HT), the neurotransmitter playing a critical role in behavioral sensitization, was found to cause long-term facilitation of Glu transmission in Aplysia and Helix neurons (Borisova and Skrebitsky, 1991; Milner et al., 1998; Chitwood et al., 2001; Antonov et al., 2003; Balaban et al., 2004)...
    • ...At present, the explanations of the enhancement of Glu response during serotonin-induced facilitation is believed to be the insertion of additional AMPA-type Glu receptors into postsynaptic membrane (Chitwood et al., 2001)...
    • ...The insertion of additional AMPA-type Glu receptors activating cationic channels into postsynaptic membrane is a popular explanation for both serotonin-induced facilitation in molluscan neurons (Chitwood et al., 2001) and LTP in hippocampus (Milner et al., 1998)...

    Julia V. Bukanovaet al. Cyclic Nucleotides Induce Long-Term Augmentation of Glutamate-Activate...

    • ...Armitage and Siegelbaum (1998) have shown that application of DNQX, an antagonist of AMPA-type receptors in Aplysia motor neurons (Dale and Kandel, 1993; Chitwood et al., 2001), does not disrupt short-term homosynaptic depression, although DNQX blocks transmission at the sensorimotor synapse...

    Youssef Ezzeddineet al. Prolonged Habituation of the Gill-Withdrawal Reflex in Aplysia Depends...

    • ...Aplysia sensory– motor neuron PSPs are thought to have both AMPA and NMDA components (Glanzman, 1994; Conrad et al., 1999; Antonov et al., 2003), and insertion of AMPA-type receptors may also contribute to facilitation by serotonin in Aplysia (Chitwood et al., 2001)...
    • ...7C,D). Intracellular Ca 2 release and CamKII are similarly thought to play some role in the spike broadening-independent component of facilitation by serotonin at Aplysia sensory–motor neuron synapses (Boyle et al., 1984; Nakanishi et al., 1997), and AMPA receptor insertion may also contribute to facilitation by serotonin in the same time range as the potentiation (around 30 min) (Chitwood et al., 2001; Li et al., 2001)...
    • ...Like homosynaptic potentiation, AMPA receptor insertion is thought to involve metabotropic receptors linked to Ca 2 release from postsynaptic IP3-sensitive stores in Aplysia (Chitwood et al., 2001; Li and Glanzman, 2002) and postsynaptic CamKII and MAP kinase in hippocampus (Malinow and Malenka, 2002)...

    Iksung Jinet al. Presynaptic and Postsynaptic Mechanisms of a Novel Form of Homosynapti...

Sort by: