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GAP43: an intrinsic determinant of neuronal development and plasticity

GAP43: an intrinsic determinant of neuronal development and plasticity,10.1016/S0166-2236(96)10072-2,Trends in Neurosciences,Larry I Benowitz,Aryeh Ro

GAP43: an intrinsic determinant of neuronal development and plasticity   (Citations: 502)
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Several lines of investigation have helped clarify the role of GAP-43 (F1, B-50 or neuromodulin) in regulating the growth state of axon terminals. In transgenic mice, overexpression of GAP-43 leads to the spontaneous formation of new synapses and enhanced sprouting after injury. Null mutation of the GAP-43 gene disrupts axonal pathfinding and is generally lethal shortly after birth. Manipulations of GAP-43 expression likewise have profound effects on neurite outgrowth for cells in culture. GAP-43 appears to be involved in transducing intra- and extracellular signals to regulate cytoskeletal organization in the nerve ending. Phosphorylation by protein kinase C is particularly significant in this regard, and is linked with both nerve-terminal sprouting and long-term potentiation. In the brains of humans and other primates, high levels of GAP-43 persist in neocortical association areas and in the limbic system throughout life, where the protein might play an important role in mediating experience-dependent plasticity.
Journal: Trends in Neurosciences - TRENDS NEUROSCI , vol. 20, no. 2, pp. 84-91, 1997
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