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Changes in the activities of hepatic xenobiotic metabolising enzymes after the administration of clenbuterol to female broilers

Changes in the activities of hepatic xenobiotic metabolising enzymes after the administration of clenbuterol to female broilers,10.1016/S0034-5288(96)

Changes in the activities of hepatic xenobiotic metabolising enzymes after the administration of clenbuterol to female broilers   (Citations: 3)
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Clenbuterol is a β2-agonist drug which in some countries is used illegally to enhance the productivity of various food-producing species, including poultry. This work investigated whether the prolonged exposure of female broilers to clenbuterol modified the activity of hepatic microsomal or cytosolic enzyme systems concerned with the metabolism of drugs, pesticides, carcinogens and endogenous substrates such as sexual steroids. Clenbuterol was added to the birds' diet at concentrations of 1 or 25 ppm for 21 days. There was a dose-related decrease in the concentration of cytochrome P-450, and in the activities of the polycyclic aromatic hydrocarbon-inducible monooxygenases ethoxyresorufm O-de-ethylase and aryl hydrocarbon hydroxylase. The activities of glutathione S-transferase, N-acetyltransferase and uridinediphosphoglucuronyltransferase were not affected by the treatment.
Journal: Research in Veterinary Science - RES VET SCI , vol. 60, no. 1, pp. 33-36, 1996
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    • ...In female broiler chicks fed for 21 days with the ß-agonist clenbuterol (CLEN), a significant decrease of CYP1A1-dependent DME activity was observed (Nebbia et al., 1996)...
    • ...N-demethylation of aminopyrine (Cantiello et al., 2002), whilst no differences were ever observed for females, even at highest doses (25 ppm: Nebbia et al., 1996)...
    • ...CYP3A expression was never affected by the treatment in the other experiments cited above and executed in poultry and meat cattle (Nebbia et al., 1996; Cantiello et al., 2002; Capolongo et al., 2004; Merlanti et al., unpublished; Dacasto et al., unpublished)...

    M. Dacastoet al. Illegal Drug Treatments and Drug Metabolism: Biomarkers or Not?

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