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The Genetics of Adaptation: A Reassessment

The Genetics of Adaptation: A Reassessment,10.1086/285437,American Naturalist,H. Allen Orr,Jerry A. Coyne

The Genetics of Adaptation: A Reassessment   (Citations: 195)
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Journal: American Naturalist - AMER NATURALIST , vol. 140, no. 5, 1992
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    • ...An important question in evolutionary biology is whether adaptation involves the accumulation of many genetic changes with small phenotypic effects or at least initially with large effects (Orr and Coyne 1992)...

    C. M. Wanget al. Mapping QTL for an Adaptive Trait: The Length of Caudal Fin in Lates c...

    • ... Although this field has been studied and discussed intensively over the past decades (reviewed in ...

    K. Henniges-Janssenet al. Complex inheritance of larval adaptation in Plutella xylostella to a n...

    • ...when a population is far from an adaptive peak, with smaller-effect mutations that act to fine-tune the phenotype to an adaptive optimum predominating during later stages of adaptation [9-11]...
    • ...These models assume directional selection moves a population up a static solitary peak in an adaptive landscape, disregarding that many adaptive landscapes harbor multiple or shifting phenotypic optima [5,9,12,13]...
    • ...However, traits under biotic selection, because they are subject to the stochastic processes that influence interacting species’ distributions and abundances, are hypothesized to be more temporally and spatially variable compared to traits under abiotic selection [9,18]...
    • ...This finding would support the geometric model of adaptation, which predicts that large-effect QTL become fixed more often when populations are farther from an adaptive peak [9-11], as they are in a shifting adaptive landscape...
    • ...Though current models provide no general prediction about the effect of shifting phenotypic optima on QTL effect size [5], QTL fixed early in an adaptive walk, or when populations are far from their phenotypic optimum, are larger than QTL fixed later [9,44]...
    • ...Populations located within striking distance of a number of adaptive peaks may make large adaptive steps towards any one of those peaks [9,45]...

    Allison M Louthanet al. Comparing the adaptive landscape across trait types: larger QTL effect...

    • ...Kimura 1983; Orr and Coyne 1992; Imhof and Schlotterer 2001; Daborn et al. 2002; Betancourt and Bolback 2006)...
    • ...Hence, beneficial mutations with large effects may be more frequent than usually believed, giving more importance to new mutations in evolution (Fisher 1930; Nei 2007; Orr and Coyne 1992; Peck 1994; Woodruff et al. 1996; Huai and Woodruff 1997, 1998 :L i1997 ;O rr1998, 2005a, b, 2009, 2010; Woodruff et al. 2004; Houle and Kondrashov 2006; Stoltzfus and Yampolsky 2009; Sniegowski and Gerrish 2010)...

    Mingcai Zhanget al. Adaptation of Drosophila melanogaster to increased NaCl concentration ...

    • ...

      Genetic basis of premating isolation

      The debate about the role of major genes in adaptation contrasts phenotypic discontinuities with gradual transitions (...

    A Widmeret al. Evolution of reproductive isolation in plants

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