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Surveyance of disease frequency in a population by linkage to diagnostic laboratory databases. A system for monitoring the incidences of hyper- and hypothyroidism as part of the Danish iodine supplementation program

Surveyance of disease frequency in a population by linkage to diagnostic laboratory databases. A system for monitoring the incidences of hyper- and hy

Surveyance of disease frequency in a population by linkage to diagnostic laboratory databases. A system for monitoring the incidences of hyper- and hypothyroidism as part of the Danish iodine supplementation program   (Citations: 10)
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In Denmark an increase in iodine intake through salt iodization has been introduced in 1998. In parallel a program for surveyance of thyroid diseases in the population was developed as recommended by UNICEF and WHO. Objective: To develop and evaluate a computer based system to identify and register new cases of hyper- and hypothyroidism in a well defined cohort, by linkage to diagnostic laboratory databases. Design and results: (1) Two sub cohorts for monitoring were defined (n=535 859), and evaluated to minimize loss of new cases. Collaboration was established with laboratories covering thyroid hormone analyses in the cohort; (2) a diagnostic algorithm was defined and evaluated against clinical practice; (3) evaluation of the laboratory methods employed by the four participating laboratories, to ensure they would reach the same diagnosis in a patient; (4) a register database was developed which used data imported from the laboratory databases to automatically identify previously unknown cases of hyper- and hypothyroidism and record diagnostic activity in the area. All parts of the registration were carefully evaluated. Conclusion: We describe for the first time a computer based system for prospective measuring the incidence rate of hyper- and hypothyroidism. The system is particularly useful for monitoring of iodine supplementation programmes.
Journal: Computer Methods and Programs in Biomedicine - CMPB , vol. 67, no. 3, pp. 209-216, 2002
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    • ...The second part of DanThyr is a register of new cases of overt hyper- and hypothyroidism in an open population cohort of more than 550 000 people living in the same two areas (Fig. 2). The details on method of identification and verification of new patients, as well as the various studies performed to evaluate the method, have been published (12)...

    Peter Laurberget al. The Danish investigation on iodine intake and thyroid disease, DanThyr...

    • ...The use of this system for identification of patients, the various types of evaluation and control performed, and detailed information on participating diagnostic laboratories and biochemical tests used for evaluation of thyroid function have been described in detail previously (25, 26)...
    • ...Our case identification system had a high sensitivity (25) and identified primarily also a number of patients not having true, incident hypothyroidism...

    Allan Carleet al. Epidemiology of subtypes of hypothyroidism in Denmark

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