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The Combined Expression Pattern of BMP2, LTBP4, and DERL1 Discriminates Malignant From Benign Canine Mammary Tumors

The Combined Expression Pattern of BMP2, LTBP4, and DERL1 Discriminates Malignant From Benign Canine Mammary Tumors,10.1177/0300985810363904,Veterinar

The Combined Expression Pattern of BMP2, LTBP4, and DERL1 Discriminates Malignant From Benign Canine Mammary Tumors   (Citations: 4)
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Journal: Veterinary Pathology - VET PATHOL , vol. 47, no. 3, pp. 446-454, 2010
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    • ...In one, LTBP4 mRNA expression decreased in a graded manner during tumor progression with a concomitant increase in LTBP1 mRNA [101, 102]...
    • ...LTBP4 was one of only three genes within a forty-nine gene signature that accurately distinguished benign from malignant tumors [101]...

    Anupama Chandramouliet al. Choreographing Metastasis to the Tune of LTBP

    • ...Both malignancies are the most common cancer of the female, lymph node metastases indicate a poor prognosis, the hormonal status influences the development of CMT and estrogen receptor (ER), progesterone receptor (PR) and ERBB2 expression patterns do influence the overall survival rate [1,16-18]...
    • ...Primer sequences, product length and sequence accession numbers for the PCR assays for AURKA, ALOX12, BMP6, ERBB4, HEPACAM2, IGFR2, RAD51, TGFBR3 and the housekeeper genes A5B, HPRT and RP32 mRNA expression levels were used before [17,21-24] and are Table 1 Tumors, lymph node status and histologic and immunohistochemical features of metastatic and nonmetastatic canine mammary carcinomas Dog Breed Age in years Histologic...
    • ...were selected due to their description in the literature on canine mammary tumors before[17,21-24,51]...
    • ...Their gene expression has been described metastatic carcinomas, metastases, adenomas and normal mammary gland and these studies showed a similar tendency of changes in gene expression between benign and malignant canine mammary tissue types[17,21-24,51]...

    Robert Klopfleischet al. Metastatic canine mammary carcinomas can be identified by a gene expre...

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