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The Well-Worn Route and the Path Less Traveled

The Well-Worn Route and the Path Less Traveled,10.1016/S0896-6273(03)00095-3,Neuron,Tom Hartley,Eleanor A. Maguire,Hugo J. Spiers,Neil Burgess

The Well-Worn Route and the Path Less Traveled   (Citations: 106)
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Finding one's way in a large-scale environment may engage different cognitive processes than following a familiar route. The neural bases of these processes were investigated using functional MRI (fMRI). Subjects found their way in one virtual-reality town and followed a well-learned route in another. In a control condition, subjects followed a visible trail. Within subjects, accurate wayfinding activated the right posterior hippocampus. Between-subjects correlations with performance showed that good navigators (i.e., accurate wayfinders) activated the anterior hippocampus during wayfinding and head of caudate during route following. These results coincide with neurophysiological evidence for distinct response (caudate) and place (hippocampal) representations supporting navigation. We argue that the type of representation used influences both performance and concomitant fMRI activation patterns.
Journal: Neuron , vol. 37, no. 5, pp. 877-888, 2003
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    • ...8 Journal of Cognitive Neuroscience Volume X, Number Y study of navigation in which wayfinding—generating novel routes based on free exploration of a virtual environment—involved the hippocampus while following a familiar route involved the caudate (Hartley, Maguire, Spiers, & Burgess, 2003)...

    Nicholas B. Turk-Browneet al. Neural Evidence of Statistical Learning: Efficient Detection of Visual...

    • ...neurophysiological grounds. Hartley et al. (2003) [32], for example, have shown that the basal...
    • ...date nucleus in the basal ganglia (Hartley et al. 2003) [32]...

    Hanspeter A. Mallotet al. Embodied spatial cognition: Biological and artificial systems

    • ...For example, the parahippocampal cortex is thought to be involved in acquiring new spatial memories (Ross, 1980; Habib and Sirigu, 1987; Aguirre et al., 1996; Barrash et al., 2000) and neuroimaging studies find retrosplenial activity during virtual navigation tasks (Maguire et al., 1997; Gro ¨n et al., 2000; Mellet et al., 2000; Hartley et al., 2003; Iaria et al., 2003; Rosenbaum et al., 2004; Kumaran and Maguire, 2005; Spiers and ...
    • ...Further, the caudate mediates stimulus-response navigation (Packard and McGaugh, 1996; Hartley et al., 2003; Iaria et al., 2003; Bohbot et al., 2004; Voermans et al., 2004; Etchamendy and Bohbot, 2007) and the parietal cortex supports remote spatial memory through egocentric mental representations (Spiers and Maguire, 2007)...
    • ...These findings are consistent with studies on rats with hippocampal damage (Morris et al., 1982) and functional magnetic resonance imaging (fMRI) studies indicating that that the hippocampus is not involved in procedurally based navigation (Hartley et al., 2003; Rauchs et al., 2008)...
    • ...Our findings are also consistent with virtual navigation tasks in which hippocampal activity correlates with spatial navigation (Hartley et al., 2003)...

    Naomi J. Goodrich-Hunsakeret al. Spatial deficits in a virtual water maze in amnesic participants with ...

    • ... functional differences between MTL regions in the processing of objects and scenes in the context of mnemonic and visual discrimination tasks, with the perirhinal cortex implicated in processing objects, including faces, and the hippocampus important for spatial scenes (Murray et al. 1989; Zhu et al. 1996; Bohbot et al. 1998, 2004; Holdstock et al. 2000; Vann et al. 2000; Buckley et al. 2001; Spiers et al. 2001; King et al. 2002; Hartley et ...

    Andy C. H. Leeet al. Activating the Medial Temporal Lobe during Oddity Judgment for Faces a...

    • ...The activity that we found in the hippocampal complex and striatum, when participants performed the familiarization phase, is consistent with the role of these brain regions in human navigation (Maguire et al., 1998; Epstein et al., 1999; Hartley et al., 2003; Iaria et al., 2003)...
    • ...Previous studies show that the hippocampus is fundamental in the creation and use of a cognitive map of the environment (Iaria et al., 2007), whereas the striatum subserves procedural memory, which allows individuals to move in an automatic manner after they have become familiar with the environment (Hartley et al., 2003; Iaria et al., 2003)...

    Giuseppe Iariaet al. Detection of unexpected events during spatial navigation in humans: bo...

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