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THE ROLE OF CYCLIC AMP IN THE INTERACTION OF GLUCAGON AND INSULIN IN THE CONTROL OF LIVER METABOLISM

THE ROLE OF CYCLIC AMP IN THE INTERACTION OF GLUCAGON AND INSULIN IN THE CONTROL OF LIVER METABOLISM,10.1111/j.1749-6632.1971.tb45239.x,Annals of The

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THE ROLE OF CYCLIC AMP IN THE INTERACTION OF GLUCAGON AND INSULIN IN THE CONTROL OF LIVER METABOLISM   (Citations: 22)
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Journal: Annals of The New York Academy of Sciences - ANN N Y ACAD SCI , vol. 185, no. 1, pp. 85-100, 2006
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    • ...In this context, it is of interest that binding of IAPP to hepatic receptors for calcitonin gene-related peptide activates adenylate cyclase [18], which catalyzes the synthesis of cyclic AMR which in turn serves as second messenger of glucagon action [19, 20]...

    M. Roden, et al. Effects of islet amyloid polypeptide on hepatic insulin resistance and...

    • ...The liver is likely to be the primary target organ and, because of its size and sensitivity to glucagon, may be the prinicipal contributor to any process of transfer of cAMP to plasma [1, 8]. This concept is supported by some observation of hepatectomized animals [5], which showed a lack of effect of glucagon on the plasma cAMP levels, but it is not certain if the plasma cAMP levels after stimulation by glucagon accurately reflect the ...

    Y. Hata, et al. Liver regeneration following portacaval shunt in rats: 3′, 5′-cyclic A...

    • ...The presence of cyclic AMP transport system was demonstrated in a variety of cells and organs including isolated superior cervical ganglion of rats (Davoren and Sutherland, 1963; Exton et aL, 1971; Lindl and Cramer, 1975; Imai et aL, 1978; Kelly et al., 1978; Barber et aL, 1980)...
    • ...While, a close correlation has been demonstrated between glucose mobilization in perfused liver (Exton et al., 1971) or augmentation of the mechanical performance of the heart (Imai et aL, 1978) in response to hormones and the amount of released cyclic AMP from these tissues but not the tissue cyclic AMP levels...

    T. Dohi, et al. Forskolin enhancement of acetylcholine-evoked cyclic AMP formation and...

    • ...It is known in the adult rat that insulin can antagonise the glycogenolytic action of glucagon in the liver [19-21]...

    K. Snell, et al. Glucose metabolism in the newborn rat: The role of insulin

    • ...Thus, it has also been suggested that an increase in cyclic GMP concentration (Hollenberg & Cuatrecasas, 1975), a decrease in cyclic AMP concentration (Exton, Lewis, Ho, Robison & Park, 1971), or an increase in cell Mg ++ (Lostroh & Krahl, 1973) mediate the effects of insulin...
    • ...Cyclic Nucleotides. It has been postulated that insulin effects are mediated by a reduction in cyclic AMP levels within the cell (Exton et al., 1971; Hollenberg & Cuatrecasas, 1975)...

    S. Grinstein, et al. Action of insulin and cell calcium: Effect of ionophore A23187

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