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The effect of Cox2 specific inhibition on direct fracture healing in the rabbit tibia

The effect of Cox2 specific inhibition on direct fracture healing in the rabbit tibia,10.1007/s00776-010-0016-0,Journal of Orthopaedic Science,David J

The effect of Cox2 specific inhibition on direct fracture healing in the rabbit tibia  
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Objective  The purpose of this study was to evaluate the effect of Cox-2 administration on direct (primary) fracture healing. Methods  A transverse tibial osteotomy was created in adult male rabbits and rigidly fixed in compression using a 2.7-mm dynamic compression plate. Animals were randomized to receive either rofecoxib (12.5 mg orally per day) or placebo. Animals were killed at 4 weeks and fracture healing assessed by mechanical testing. Results  There were no significant differences between the control and Cox-2 treated animals in terms of mechanical strength at 4 weeks. There was a high complication rate of peri-implant fractures during the daily medication administration. Conclusion  The immediate administration of a Cox-2 specific inhibitor did not impair primary (direct) bone healing at the dose administered in this rabbit tibial osteotomy model.
Journal: Journal of Orthopaedic Science - J ORTHOP SCI , vol. 16, no. 1, pp. 93-98, 2011
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