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In vitro inhibitory effect of trichostatin A on canine grade 3 mast cell tumor

In vitro inhibitory effect of trichostatin A on canine grade 3 mast cell tumor,10.1007/s11259-011-9474-x,Veterinary Research Communications,Marcia Kaz

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In vitro inhibitory effect of trichostatin A on canine grade 3 mast cell tumor  
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Mast cell tumor (MCT) is one of the most prevalent neoplasms that affect skin and soft tissue in dogs. Because mast cell tumors present a great variety of clinical appearance and behavior, their treatment becomes a challenge. Trichostatin A (TSA), an antifungal antibiotic, has shown inhibitory effects on the proliferation and induction of apoptosis in various types of cancer cells. In order to evaluate the potential of trichostatin A as a therapeutic drug, cells of grade 3 MCT were cultured and treated with concentrations of 1 nM to 400 nM of TSA. MTT assay and trypan blue exclusion assays were performed to estimate cell growth and cell viability, and cell cycle analysis was evaluated. TSA treatment showed a reduction in numbers of viable cells and an increase of cell death by apoptosis. The cell cycle analysis showed an increase of hypodiploid cells and a reduction of G0/G1 and G2/M –phases. According to these results, trichostatin A may be an interesting potential chemotherapeutic agent for the treatment of canine MCT.
Journal: Veterinary Research Communications - VET RES COMMUN , pp. 1-9
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