Helicobacter pylori seropositivity in fibromyalgia syndrome

Helicobacter pylori seropositivity in fibromyalgia syndrome,10.1007/s10067-010-1618-9,Clinical Rheumatology,Nuray Akkaya,Semih Akkaya,Yusuf Polat,Mera

Helicobacter pylori seropositivity in fibromyalgia syndrome   (Citations: 1)
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Although there are some studies suggesting relation between different types of infection and fibromyalgia syndrome (FM), there is presently no proof that FM is caused by an infection. Helicobacter pylori (HP) infection may cause extragastric manifestations. Inflammation is an important mediator of increased sympathetic nervous system activity and may lead to pain in fibromyalgia patients. In this study, we aimed to investigate the HP seropositivity in fibromyalgia patients compared with controls for possible role of HP infection in FM. Sixty-seven patients with fibromyalgia were evaluated. Two of them were excluded from the study because of high level of acute phase reactants. Sixty-five female patients with fibromyalgia and 41 randomly selected age-matched female healthy controls were enrolled to study. Serum HP IgA and IgG antibodies were measured by enzyme-linked immunosorbent assay technique. Fibromyalgia Impact Questionnaire was assessed in patients and controls. Seropositivity of HP IgG antibody in the fibromyalgia patients was significantly higher than in the control group. No statistically significant differences were found regarding the clinical features between fibromyalgia patients with HP IgG antibody and patients without IgG antibody. Our study suggests that former HP infection may have a role in the etiopathogenesis of fibromyalgia syndrome or may act as a triggering factor. However, high seroprevalence of HP in general population and prevalent asymptomatic infection make it difficult to interpret these results for the definite role of HP in FM. Highlighting the pathophysiologic mechanisms of FM will result in more effective treatment regimens.
Journal: Clinical Rheumatology - CLIN RHEUMATOL , vol. 30, no. 1, pp. 43-49, 2011
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    • ...In the paper by Akkaya N, et al., Helicobacter pylori (H. pylori) infection was evaluated in 65 patients with fibromyalgia syndrome (FM) and in 41 healthy controls, using two different serological methods [1]...
    • ...Furthermore, it was demonstrated that this test possesses an even lower overall accuracy rate in the ages over 18 years (51.8%) [2], thereby rendering it practically useless and a waste of time and resources for the patients evaluated in the study by Akkaya N, et al. [1]...
    • ...Therefore, this comes to no surprise why the authors found no significant difference in the prevalence of H. pylori IgA antibodies between their FM patients and controls (p=0.169) [1]...
    • ... significant differences regarding mainly the clinical features (sleep disturbance, fatigue, stiffness, headache, subjective soft-tissue swelling, paresthesia, dysmenorrhea, female urethral syndrome, irritable bowel syndrome, and anxiety), anxiety and depression subscale of Fibromyalgia Impact Questionnaire, history of depression, and previous treatment for depression between the two study groups (FM patients and controls) [1]...

    Christos Zavoset al. Association between Helicobacter pylori infection and fibromyalgia syn...

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