A Novel Mechanical Thrombectomy Device for Retrieval of Intravascular Thrombus
Purpose Thrombotic and embolic vascular occlusion represents a leading cause of morbidity and mortality. Currently available thrombectomy
devices have limitations, including difficulty removing organized thrombus and clot fragmentation with distal embolization.
A novel mechanical thrombectomy device (MTD), designed to remove both hard and soft thrombus without trauma to the blood vessel,
was tested in preclinical porcine models evaluating efficacy, safety, and ease of use.
Materials and Methods A total of 26 vessels in 14 pigs underwent mechanical thrombectomy with MTD. Thrombectomy was performed in nine superficial
femoral arteries, eight subclavian arteries, five primary branches of the subclavian artery, lateral thoracic artery or the
thyrocervical trunk, and four external carotids. Subacute organized fibrin-laden thrombus was injected into the arteries producing
vascular occlusion. The MTD was then used for thrombectomy to restore patency and blood flow.
Results Intact thrombus was retrieved from 24 of 26 of the vessels with a single pass of the MTD, resulting in complete restoration
of patency in 21 vessels and partial patency in 4 vessels. In 8 cases that used an early design, the embolic material fragmented
during withdrawal from the access sheath. In 4 procedures that used an early design, the MTD failed to deploy fully and the
embolus was not completely captured. No intraprocedural complications or vascular damage occurred.
Conclusions The present pilot studies demonstrate basic safety and efficacy of a novel MTD with design attributes suitable for retrieval
of intact acute and organized chronic thrombus. The device has potential intracranial and peripheral utility.