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Tako-tsubo cardiomyopathy in a patient with bilateral lesions in the dorsal medulla

Tako-tsubo cardiomyopathy in a patient with bilateral lesions in the dorsal medulla,10.1007/s10286-010-0088-0,Clinical Autonomic Research,Koldo Bergan

Tako-tsubo cardiomyopathy in a patient with bilateral lesions in the dorsal medulla   (Citations: 1)
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Tako-tsubo-like cardiomyopathy (TTC) is much more common than originally thought. The exact pathophysiology of TTC is unclear. The most accepted theory proposes myocardial stunning of neurogenic origin, supported by the frequent antecedent of emotional or physical stress, suggesting a catecholamine-mediated mechanism. We present a patient with this syndrome and bilateral damage of the dorsal medulla oblongata likely affecting both solitary tract nuclei. Our case points to a link between baroreflex failure and TTC, highlighting the important role of sympathetic discharge in the pathophysiology of TTC.
Journal: Clinical Autonomic Research - CLIN AUTON RES , vol. 21, no. 1, pp. 65-67, 2011
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    • ...On the other hand, brainstem damage in the region of the solitary tract nuclei may result in a transient cardiomyopathy [8]...
    • ...A recent case report about an acute disseminated encephalomyelitis associated with Mycoplasma pneumoniae infection shows bilateral inflammatory lesion in the dorsal medulla oblongata that preceded takotsubo cardiomyopathy, affecting both solitary tract nuclei [8]...

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