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A component-based implementation of multiple sequence alignment

A component-based implementation of multiple sequence alignment,10.1145/952532.952559,Umit Catalyurek,Mike Gray,Tahsin M. Kurç,Joel H. Saltz,Eric Stah

A component-based implementation of multiple sequence alignment   (Citations: 7)
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This paper addresses the efficient execution of a Multiple Sequence Alignment (MSA) method, in particular the progressive alignment-based CLUSTAL W algorithm, on a cluster of workstations. We describe a scalable component-based implementation of CLUSTAL W program targeting distributed memory machines and multiple query workloads. We look at the effect of data caching on the performance of the data server. We present a distributed, persistent cache approach for caching intermediate results for reuse in subsequent or concurrent queries. Our initial results show that the cache-enabled CLUSTAL W program scales well on a cluster of workstations.
Conference: ACM Symposium on Applied Computing - SAC , pp. 122-126, 2003
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