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The Effects of Pesticides on Immune Cells

The Effects of Pesticides on Immune Cells,10.1007/978-90-481-3892-0_62,Sogo Nishimoto,Kota Kanda,Masaaki Okabe,Koichi Akiyama,Yoshimi Kakinuma,Takuya

The Effects of Pesticides on Immune Cells  
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The environmental pollution induced by the chemical substances is regarded as a serious problem, and has various influences on the ecosystem. Recently, many people are interested in safety of foods. We focused on the pesticide chemicals presently used on farm in many countries, and chose methoxychlor and endosulfan. To investigate the influence of methoxychlor and endosulfan on immunoglobulin production, human hybridoma HB4C5 cells and mouse splenic lymphocytes were cultured in the medium containing these compounds at various concentrations. As a result, human IgM production of HB4C5 cells was slightly decreased in a dose-dependent manner. On the other hand, mouse splenic lymphocytes treated with each pesticide were markedly decreased both IgA and IgG production level except for IgM. Moreover, to assess the influence of methoxychlor and endosulfan in the body, we examined the effects of these compounds on mice by oral administration. The spleen was remarkably atrophied whereas the body weights were same as a control group. In addition, the weight loss was observed not only in liver and kidney. These results suggest that these pesticides affect immune system as well as detoxification tissues. It is supposed from these results that the exposure to these compounds via foods leads us to the decline in immune activity of our body, resulting in immune diseases.
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