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In vitro and in vivo assessment of silver-coated polypropylene mesh to prevent infection in a rat model

In vitro and in vivo assessment of silver-coated polypropylene mesh to prevent infection in a rat model,10.1007/s00192-010-1330-y,International Urogyn

In vitro and in vivo assessment of silver-coated polypropylene mesh to prevent infection in a rat model   (Citations: 2)
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Introduction and hypothesis  The purpose of this study is to determine the effect of silver coating of polypropylene implants on infection in hernia surgery. Methods  Silver-coated and non-silver-coated large pore monofilament polypropylene mesh implants were compared with and without infection (four groups). The implants were inserted in the abdominal wall of female Wistar rats. An Escherichia coli strain was inoculated intraoperatively in the two infected groups. The implants were removed, and clinical, bacteriological, and histological analyses were performed at 2, 15, and 30 days postoperatively. Results  Eighty-four rats were studied. All inoculated rats (n = 21) in the non-silver-coated polypropylene group presented periprosthetic E. coli infection, compared with only five inoculated rats in the silver-coated polypropylene group (p p < 0.01). There was no histological difference between the four groups. Conclusions  Silver-coated implants appear effective against bacterial infection in our rat model, with good histological tolerance but delayed healing.
Journal: International Urogynecology Journal - INT UROGYNECOL J , vol. 22, no. 3, pp. 265-272, 2011
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