Academic
Publications
Non-conventional sources of peptides presented by MHC class I

Non-conventional sources of peptides presented by MHC class I,10.1007/s00018-011-0655-0,Experientia,Shelley R. StarckNilabh Shastri,Nilabh Shastri

Non-conventional sources of peptides presented by MHC class I   (Citations: 2)
BibTex | RIS | RefWorks Download
Effectiveness of immune surveillance of intracellular viruses and bacteria depends upon a functioning antigen presentation pathway that allows infected cells to reveal the presence of an intracellular pathogen. The antigen presentation pathway uses virtually all endogenous polypeptides as a source to produce antigenic peptides that are eventually chaperoned to the cell surface by MHC class I molecules. Intriguingly, MHC I molecules present peptides encoded not only in the primary open reading frames but also those encoded in alternate reading frames. Here, we review recent studies on the generation of cryptic pMHC I. We focus on the immunological significance of cryptic pMHC I, and the novel translational mechanisms that allow production of these antigenic peptides from unconventional sources.
Journal: Experientia , vol. 68, no. 9, pp. 1471-1479, 2011
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
Sort by: