mTOR links oncogenic signaling to tumor cell metabolism

mTOR links oncogenic signaling to tumor cell metabolism,10.1007/s00109-011-0726-6,Journal of Molecular Medicine-jmm,Jessica L. Yecies,Brendan D. Manni

mTOR links oncogenic signaling to tumor cell metabolism   (Citations: 3)
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As a key regulator of cell growth and proliferation, the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) has been the subject of intense investigation for its role in tumor development and progression. This research has revealed a signaling network of oncogenes and tumor suppressors lying upstream of mTORC1, and oncogenic perturbations to this network result in the aberrant activation of this kinase complex in the majority of human cancers. However, the molecular events downstream of mTORC1 contributing to tumor cell growth and proliferation are just coming to light. In addition to its better-known functions in promoting protein synthesis and suppressing autophagy, mTORC1 has emerged as a key regulator of cellular metabolism. Recent studies have found that mTORC1 activation is sufficient to stimulate an increase in glucose uptake, glycolysis, and de novo lipid biosynthesis, which are considered metabolic hallmarks of cancer, as well as the pentose phosphate pathway. Here, we focus on the molecular mechanisms of metabolic regulation by mTORC1 and the potential consequences for anabolic tumor growth and therapeutic strategies.
Journal: Journal of Molecular Medicine-jmm , vol. 89, no. 3, pp. 221-228, 2011
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    • ...Public Health, Boston USA) review the role of the mammalian target of rapamycin (mTOR) as a key regulator of cell growth and proliferation whose activity is often dysregulated in cancer cells [5]...

    Gregg L. Semenza. A return to cancer metabolism

    • ...There is increasing evidence that mTOR may be a key regulator of cell growth and metabolism [42 ]( Fig.5)...
    • ...Despite all the studies discussed above linking mTOR with hypoxia (Fig. 5), the correlation between hypoxic effects on mTOR pathway and glucose oxidative metabolism remains incompletely understood although recent advances in cancer cell metabolism may provide some new insights into this mechanistic connection [42]...

    Vikas V. Dukhandeet al. Chronic hypoxia-induced alterations of key enzymes of glucose oxidativ...

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