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Anatomy of the human nucleus accumbens: a combined morphometric study

Anatomy of the human nucleus accumbens: a combined morphometric study,10.1007/s00276-010-0766-6,Surgical and Radiologic Anatomy,Ioannis Mavridis,Efsta

Anatomy of the human nucleus accumbens: a combined morphometric study   (Citations: 1)
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Purpose  The human nucleus accumbens (NA), which belongs to the basal ganglia of the brain, is the main part of the ventral striatum. The purpose of our clinically oriented anatomical-radiologic study was to provide anatomical and imaging data of the human NA, primarily useful to neurosurgeons. Methods  For our imaging study, we used cerebral magnetic resonance images (MRIs) from 26 neurosurgical patients (52 NAs). The material for our anatomic study consisted of 32 cerebral hemispheres (32 NAs) from 18 normal human brains which we have in our department (Department of Anatomy) from cadaver donors. We measured and analyzed the dimensions of the NA at specific clinically important transverse, coronal and sagittal levels. Results  The human NA suffers from age-related but no side- or sex-related morphometric changes. In surgically important stereotactic levels this nucleus is easily identifiable on MRIs. Conclusions  We present an anatomic guide of the NA from carefully measured data of our extensive and combined study and we hope that our work will be really helpful to neuroscientists interested in the NA.
Journal: Surgical and Radiologic Anatomy - SURG RADIOL ANATOMY , vol. 33, no. 5, pp. 405-414, 2011
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    • ...morphometry [21], as well as its parkinsonism-related morphometric changes [22]...
    • ...In both our imaging and anatomic studies, we chose the anterior border of the AC at the midline as the reference point with stereotactic coordinates (X, Y, Z) = (0, 0, 0), because it is the first and most often reported reference point of stereotactic coordinates used for NA DBS [4, 13, 15‐17, 19, 25, 28, 29, 31] and, in our opinion, the most reliable (it does not depend on AC‐PC distance) [21]...
    • ...The three-dimensional levels for both our studies, were chosen after careful review of the worldwide existing clinical experience of NA stereotactic surgery [21]...
    • ...Hence we chose the level Z =- 4 for our imaging study of the NA [21]...
    • ...Hence we chose the level Y =2 for both our imaging and anatomic studies of the NA [21]...
    • ...Hence we chose the level X = 8 for our imaging study of the NA [21]...
    • ...We chose the level Z = 0 (AC‐PC plane) because it is a well established reference level in stereotactic surgery [21] and it was already (prior to any section) identified at the internal hemispheric surface of the studied hemispheres, due to our methodology...
    • ...Hence we chose the level X =7 for our anatomic study of the NA [21]...
    • ...Interestingly, the latter was set under consideration by our recent results regarding NA morphometry [21]...

    Ioannis Mavridiset al. Stereotactic anatomy of the human nucleus accumbens: from applied math...

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