Academic
Publications
Analysis of Association of the Col1a1 Gene Alleles with the Risk of Osteoporosis

Analysis of Association of the Col1a1 Gene Alleles with the Risk of Osteoporosis,10.1023/A:1021656309758,Russian Journal of Genetics,M. V. Moskalenko,

Analysis of Association of the Col1a1 Gene Alleles with the Risk of Osteoporosis  
BibTex | RIS | RefWorks Download
Allele frequencies of the G ? T polymorphism at the regulatory region of the Col1a1 gene in the population of the northwestern Russia (control group) and in osteoporotic patients were estimated by the RFLP method based on PCR-mediated site-directed mutagenesis. Three patient groups with radiologically confirmed osteoporosis were examined. Group 1 consisted of 64 patients with severe osteoporosis complicated by fractures (SO); group 2 included 15 children with idiopathic osteoporosis (IO); group 3 consisted of 98 women with postmenopausal osteoporosis developed at the background of estradiol-deficiency state (PMO). The frequency of functionally defective allele s in the control group was 16.7%. It was statistically different from that in the SO patients (48.4%) (P P s in the PMO patients constituted 23% and it was similar to that in the control group (P > 0.05). Analysis of the Col1a1 alleles provides early detection of the individuals with hereditary predisposition to osteoporosis and prophylaxis of the disease at the presymptomatic stage.
Journal: Russian Journal of Genetics - RUSS J GENET , vol. 38, no. 12, pp. 1443-1446, 2002
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.