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Expression of the human cancer/testis antigen NY-SAR-35 is activated by CpG island hypomethylation

Expression of the human cancer/testis antigen NY-SAR-35 is activated by CpG island hypomethylation,10.1007/s10529-011-0559-y,Biotechnology Letters,Jin

Expression of the human cancer/testis antigen NY-SAR-35 is activated by CpG island hypomethylation  
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The novel cancer/testis antigen gene, NY-SAR-35, is expressed exclusively in normal testis and in various histological types of tumor. However, the NY-SAR-35 gene expression is observed to be aberrant in several cancer cell lines and tissues. The analysis of methylation status of the NY-SAR-35 gene promoter in various cancer cell lines showed that its expression was related to methylation of the promoter region. Treatment of human cancer cell lines with the demethylating agent 5-aza-2′-deoxycytidine activated the expression of the NY-SAR-35 gene. In addition, transfection experiments on various fragments of the CpG-rich gene promoter indicate that in vitro methylation of the NY-SAR-35 gene promoter results in the loss of promoter activity. The expression of NY-SAR-35 is therefore activated by hypomethylation of the CpG island in the gene promoter.
Journal: Biotechnology Letters - BIOTECHNOL LETT , vol. 33, no. 6, pp. 1085-1091, 2011
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