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Role of Tip60 tumor suppressor in DNA repair pathway

Role of Tip60 tumor suppressor in DNA repair pathway,10.1007/s11434-011-4433-z,Chinese Science Bulletin,ZhiJian Liu,YingLi Sun

Role of Tip60 tumor suppressor in DNA repair pathway  
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To prevent the damage caused by DNA strand breaks, eukaryotic cells have evolved a series of highly conserved DNA repair mechanisms. The ubiquitously expressed acetyltransferase, Tip60, plays a central role in ATM (ataxia-telangiectasia mutated) activation which is involved in DNA repair. Recent work uncovered a new mechanism of ATM activation mediated by Tip60 and demonstrated that histone methylation, specifically, trimethylation of histone H3, is a key factor in the process. Here, we review the current understanding of how Tip60 is activated and how it activates ATM in response to DNA damage.
Journal: Chinese Science Bulletin - CHIN SCI BULL , vol. 56, no. 12, pp. 1212-1215, 2011
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