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Influence of insulin on cyclic 3′,5′AMP phosphodiesterase activity in liver, skeletal muscle, adipose tissue, and kidney

Influence of insulin on cyclic 3′,5′AMP phosphodiesterase activity in liver, skeletal muscle, adipose tissue, and kidney,10.1007/BF01211766,Diabetolog

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Influence of insulin on cyclic 3′,5′AMP phosphodiesterase activity in liver, skeletal muscle, adipose tissue, and kidney   (Citations: 22)
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Summary  Influence of insulin on liver glycogen metabolism and on lipolysis appears to be mediated by a decreased intracellular 3,5-AMP concentration. Reduced formation of 3,5-AMP had been shown in adipose tissue incubated with insulin. The influence of insulin on 3,5-AMP degradation has been investigated. — 3,5-AMP phosphodiesterase (PDE) activity was reduced in liver, adipose tissue and, insignificantly, in skeletal muscle of insulin deficient, i.e. alloxan diabetic or starved rats. I.V. injection of a low dose of insulin (0.5 U/kg) or stimulation of endogenous insulin secretion by injection of glucose led to a rapid increase of PDE activity in these tissues. 15 min after insulin injection liver PDE activity was increased. The maximal effect occurred after 30–45 min. Renal PDE activity was not decreased in alloxan diabetes, insulin injection has been found ineffective. —In vitro, there was an activating effect of crystalline insulin on PDE purified from beef heart. Insulin concentration required for duplication of enzyme activity was of the order of 2 · 10–5 M. Treatment with actinomycin D nearly prevented stimulation of liver PDE by insulin. This may indicate that the action of insulin on PDE activity is essentially based on an increased enzyme synthesis. — Owing to the influence of insulin secretion on liver and adipose tissue 3,5-AMP concentration, glycogen metabolism and lipolysis can be quickly adapted to food intake.
Journal: Diabetologia , vol. 4, no. 6, pp. 322-329, 1968
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    • ...Insulin stimulates the membrane-bound low Km cyclic AMP phosphodiesterase, in the case of incubation with intact fat cells [4-6], hepatocytes [4, 7] and muscle [4, 8]. This enzyme seems to be associated with the endoplasmic reticulum [6]...
    • ...Insulin stimulates the membrane-bound low Km cyclic AMP phosphodiesterase, in the case of incubation with intact fat cells [4-6], hepatocytes [4, 7] and muscle [4, 8]. This enzyme seems to be associated with the endoplasmic reticulum [6]...
    • ...Insulin stimulates the membrane-bound low Km cyclic AMP phosphodiesterase, in the case of incubation with intact fat cells [4-6], hepatocytes [4, 7] and muscle [4, 8]. This enzyme seems to be associated with the endoplasmic reticulum [6]...

    T. Suzuki, et al. Insulin-sensitive phosphodiesterase and insulin receptor binding in fa...

    • ...During diabetes, cyclic AMPphosphodiesterase (PDE) activity was depressed in these ceils but was restored with insulin administration [14, 19]...
    • ...However, the effect appeared to be primarily on the low K m, Ca2+-insensitive form of the membrane enzyme [8, 14, 19]...

    A. F. Ofulue, et al. Effects of streptozotocin-induced diabetes on calmodulin and cyclic AM...

    • ...As suggested before [53] they found an effect of insulin upon the 'low K M enzyme' [52]...

    K. D. Hepp. Studies on the mechanism of insulin action: Basic concepts and clinica...

    • ...It has been reported that phosphodiesterase activity is decreased in diabetic adipose tissue [27]...

    J. Zapf, et al. Increased sensitivity of diabetic rat adipose tissue towards the lipol...

    • ...Since glucocorticoids have a chronic action upon mammary glands (18, 19, 20) and alter phosphodiesterase activities in adipose, liver, and muscle (24), and since insulin acts upon mammary glands in an acute fashion and upon other tissues via the cAMP system (17, 10, 11, 23), experiments were designed to identify effects of chronic glucocorticoid and acute insulin insufficiencies upon the mammary gland cAMP system...

    S. L. LOUIS, et al. Effect of Adrenolectomy ond Insulin Insufficiency Upon the Adenosine 3...

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