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Abnormalities of T cell signaling in systemic lupus erythematosus

Abnormalities of T cell signaling in systemic lupus erythematosus,10.1186/ar3251,Arthritis Research & Therapy,Vaishali R Moulton,George C Tsokos

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Abnormalities of T cell signaling in systemic lupus erythematosus  
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Systemic lupus erythematosus (SLE) is an autoimmune disease resulting from a loss of tolerance to multiple self antigens, and characterized by autoantibody production and inflammatory cell infiltration in target organs, such as the kidneys and brain. T cells are critical players in SLE pathophysiology as they regulate B cell responses and also infiltrate target tissues, leading to tissue damage. Abnormal signaling events link to defective gene transcription and altered cytokine production, contributing to the aberrant phenotype of T cells in SLE. Study of signaling and gene transcription abnormalities in SLE T cells has led to the identification of novel targets for therapy.
Journal: Arthritis Research & Therapy - ARTHRITIS RES THER , vol. 13, no. 2, pp. 1-10, 2011
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