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The Development and Stability of the Genus Bacteriodes from Human Gut Microbiota in HFA Mice Model

The Development and Stability of the Genus Bacteriodes from Human Gut Microbiota in HFA Mice Model,10.1007/s00284-010-9833-9,Current Microbiology,Jing

The Development and Stability of the Genus Bacteriodes from Human Gut Microbiota in HFA Mice Model  
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Human flora-associated (HFA) mice are frequently applied in studying the ecology and metabolism of human gut microbiota. However, the development and stability of the genus Bacteriodes, a prominent bacteria group of human gut microbiota, in HFA mice have not yet fully been examined. In this study, PCR-denaturing gradient gel electrophoresis (DGGE) analysis was employed to monitor the Bacteriodes community in the fecal microbiota of six HFA Kunming mice during a period of 3 weeks. Based on the DGGE banding patterns, the majority of prominent bands in the HFA mice DGGE profile were also typical bands in the human DGGE profile, despite the absence of three bands (corresponding to two different B. thetaiotaomicron strains and one B. intestinalis strain) from the human DGGE profile. The Dice coefficient of similarity for the fecal microbiota of HFA mice in comparison to the human donor sample ranged between 74 ± 6% and 81 ± 7%. The phylogeny of bands in the DGGE profile showed that the dominant Bacteriodes species in the fecal microbiota of HFA mice were B. thetaiotaomicron, representing 66.7% of all bands. Our results indicate that the genus Bacteriodes in the fecal microbiota of HFA mice was selected from the human donor and could remain relatively stable over time.
Journal: Current Microbiology - CURR MICROBIOL , vol. 62, no. 4, pp. 1107-1112, 2011
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