Coffee consumption may influence hippocampal volume in young women
Gabor Perlaki, Gergely Orsi, Norbert Kovacs, Attila Schwarcz, Zilia Pap, Zsuzsanna Kalmar, Eniko Plozer, Arpad Csatho, Robert Gabriel, Samuel Komoly, Imre Janszky, József Janszky
Caffeine is the most often used psychoactive substance. Caffeine may influence neuroplasticity in animals. We investigated
the relationship between caffeine intake (coffee consumption) and brain morphology. Forty-five healthy, non-smoking women
aged 19–30 were included in the present study. We used semi-automatic user-independent MR volumetry and voxel-based morphometry.
We investigated the relationship between caffeine intake (coffee consumption) and the volumes of the cortical brain structures
where caffeine is supposed to act. We found that high-level and low-level caffeine intake was associated with a larger hippocampus
compared to moderate-level caffeine intake. The other brain structures showed no association with coffee consumption or caffeine
intake. The U-shape association between caffeine concentration and its effect has already been described in some experimental
studies. To our knowledge this is one of the very first studies, which tries to find an association between brain morphology
and coffee consumption or caffeine intake in humans using MR imaging.