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Pigment epithelium-derived factor expression is down-regulated in bladder tumors and correlates with vascular endothelial growth factor and matrix metalloproteinase-9

Pigment epithelium-derived factor expression is down-regulated in bladder tumors and correlates with vascular endothelial growth factor and matrix met

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Pigment epithelium-derived factor expression is down-regulated in bladder tumors and correlates with vascular endothelial growth factor and matrix metalloproteinase-9   (Citations: 1)
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Growth of solid tumor depends on angiogenesis, a process regulated by the balance of pro- and anti-angiogenic factors. We investigated the expression of anti-angiogenic factor pigment epithelium-derived factor (PEDF) and proangiogenic factors vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) with immunohistochemistry in 64 bladder tumor samples and 23 normal controls. Compared with normal urothelium, we identified decreased PEDF expression (P = 0.000) whereas increased expression of VEGF (P = 0.000) and MMP-9 (P = 0.000) in tumorous tissue as well as in papillary urothelial neoplasm of low malignant potential (PUNLMP) (P = 0.009 and P = 0.000 accordingly) but MMP-9 (P = 0.704). Decreased PEDF expression was revealed with higher tumor grade (P = 0.014) but stage (P = 0.687). There was no age or gender preference in PEDF, VEGF or MMP-9 expression. Negative correlation of expression in tumorous and cancerous tissue regarding PEDF and VEGF (P = 0.000, r = −0.56, and P = 0.000, r = −0.50, respectively), PEDF and MMP-9 (P = 0.002, r = −0.39, and P = 0.032, r = −0.30, respectively) was identified. There was a negative correlation of expression between PEDF and VEGF (P = 0.016, r = −0.677) and no correlation between PEDF and MMP-9 (P = 0.147, r = −0.45) in PUNLMP. Decreased PEDF and increased VEGF and MMP-9 expression may play considerable roles in differentiation and invasion of bladder tumor.
Journal: International Urology and Nephrology - INT UROL NEPHROL , vol. 43, no. 2, pp. 383-390, 2011
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    • ...Our preliminary study shows that PEDF is in negative correlation with proangiogenic factors like vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in bladder tumours, indicating a possible antiangiogenic effect of PEDF [11] . Nonetheless, mechanism by which PEDF exerts its function in bladder tumour remain unclear...

    Chenchen Feng, et al. Expression of pigment epithelium-derived factor in bladder tumour is c...

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