Academic
Publications
Prognostic Value of Quality of Life and Pain in Patients with Locally Recurrent Rectal Cancer

Prognostic Value of Quality of Life and Pain in Patients with Locally Recurrent Rectal Cancer,10.1245/s10434-010-1218-6,Annals of Surgical Oncology,Y.

Prognostic Value of Quality of Life and Pain in Patients with Locally Recurrent Rectal Cancer   (Citations: 1)
BibTex | RIS | RefWorks Download
Background  Care of patients with locally recurrent rectal cancer (LRRC) requires careful patient selection. While curative resection offers survival benefits, significant trade-offs exist for the patient. Knowledge of patient-reported outcomes will help inform treatment decisions. Methods  Quality of life (QOL) and pain were prospectively assessed in 105 patients treated for LRRC at a single institution, using the validated Functional Assessment of Cancer Therapy-Colorectal (FACT-C) and Brief Pain Inventory (BPI) questionnaires. In 54 patients enrolled and followed from diagnosis of LRRC, relationship between pretreatment pain, QOL, and overall survival (OS) were examined. Results  Patients underwent curative surgical resection (C, 59%), noncurative surgery (NC, 12%) or nonsurgical treatment (NS, 28%). Median OS was 7.1, 1.4, and 1.9 years, respectively (C versus NC: p p = 0.006; NC versus NS: p = 0.261). Physical well-being QOL differed over time (p = 0.042), with greatest difference between C and NC surgery patients (p = 0.049). The remaining QOL domain scores and pain scores demonstrated no significant time or treatment effect. For the 54 patients assessed from diagnosis, median OS was independently predicted by treatment group (C, NC, NS: 4.3, 1.7, versus 2.4 years; p  4: 3.8 versus 2.0 years; p = 0.001). Conclusion  Curative surgery offered prolonged survival, but significant pain exists among long-term survivors and should be a focus of survivorship care. Noncurative surgery did not offer apparent advantages over nonsurgical palliation. Patient’s pretreatment pain has prognostic value, and should be assessed, treated, and considered in treatment decisions.
Journal: Annals of Surgical Oncology - ANNALS SURG ONCOLOGY , vol. 18, no. 4, pp. 989-996, 2011
Cumulative Annual
View Publication
The following links allow you to view full publications. These links are maintained by other sources not affiliated with Microsoft Academic Search.
Sort by: