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Engineered droplets for dried droplet solute deposition by mass spectrometric imaging

Engineered droplets for dried droplet solute deposition by mass spectrometric imaging,10.1007/s10404-011-0781-x,Microfluidics and Nanofluidics,Ville J

Engineered droplets for dried droplet solute deposition by mass spectrometric imaging  
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Solute deposition patterns of peptides are studied on dried droplet deposits from engineered droplet shapes using surface assisted laser desorption ionization mass spectrometric imaging. The engineered droplet shapes are achieved through superhydrophilic/hydrophobic patterned surfaces. Strong pinning of the contact line to the edges of the hydrophilic area causes the solutes to deposit mostly to the perimeter of the hydrophilic area on simple circular and square shaped spots. More complex geometries resulted in unique deposition patterns, showing potential for spotting and chemical analysis. In particular, a geometry where the analyte was split and concentrated onto eight discrete target sites is described. The deposition patterns of analyte mixtures are also studied, and spatial separation is observed between various analytes, enabling the possibility for analyte separation.
Journal: Microfluidics and Nanofluidics - MICROFLUID NANOFLUID , vol. 11, no. 2, pp. 145-156, 2011
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