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Transcriptional regulation by nonclassical action of thyroid hormone

Transcriptional regulation by nonclassical action of thyroid hormone,10.1186/1756-6614-4-S1-S6,Thyroid Research,Lars C Moeller,Martina Broecker-Preuss

Transcriptional regulation by nonclassical action of thyroid hormone   (Citations: 1)
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Abstract  Thyroid hormone (TH) is essential for normal development, growth and metabolism. Its effects were thought to be principally mediated through triiodothyronine (T3), acting as a ligand for the nuclear TH receptors (TRs) α and β residing on thyroid hormone response elements (TREs) in the promoter of TH target genes. In this classical model of TH action, T3 binding to TRs leads to recruitment of basal transcription factors and increased transcription of TH responsive genes. Recently, the concept of TH action on gene expression has become more diverse and now includes nonclassical actions of T3 and T4: T3 has been shown to activate PI3K via the TRs, which ultimately increases transcription of certain genes, e.g. HIF-1α. Additionally, both T3 and thyroxine (T4) can bind to a membrane integrin, αvβ3, which leads to activation of the PI3K and MAPK signal transduction pathways and finally also increases gene transcription, e.g. of the FGF2 gene. Therefore, these initially nongenomic, nonclassical actions seem to serve as additional interfaces for transcriptional regulation by TH. Aim of this perspective is to summarize the genes that are currently known to be induced by nonclassical TH action and the mechanisms involved.
Journal: Thyroid Research - Thyroid Res , vol. 4, pp. 1-7, 2011
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    • ...The impact and perspectives of these recent findings are summarized by Möller and Bröcker-Preuß [6] who comment on the outcomes of activation of alternative signaling pathways on transcriptional regulation of TH target cells...

    Heike Biebermann. What is hot in experimental thyroidology?

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