Mild Cognitive Impairment in Parkinson’s Disease

Mild Cognitive Impairment in Parkinson’s Disease,10.1007/s11910-011-0203-1,Current Neurology and Neuroscience Reports,Dag Aarsland,Kolbjørn Brønnick,T

Mild Cognitive Impairment in Parkinson’s Disease   (Citations: 2)
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Prospective studies conducted during the last decade have shown that the majority of patients with Parkinson’s disease (PD) develop dementia. In addition, using a variety of definitions and methods, more recent research suggests that approximately a quarter of PD patients without dementia have mild cognitive impairment (PD-MCI). Furthermore, several studies have shown that approximately 20% have MCI even at time of diagnosis of PD. The typical cognitive deficits include visuospatial, attentional, and executive deficits, but memory deficits have also been shown. The etiology of PD-MCI is not known, but it is likely that mechanisms known to contribute to dementia in PD (ie, limbic and cortical Lewy bodies, amyloid plaques, and cholinergic deficits) play a role, in addition to dysfunction of dopaminergic frontostriatal circuits. PD-MCI predicts a shorter time to dementia, and preliminary evidence suggests that this is particularly true for posterior cognitive deficits. There are currently no systematic clinical trials in PD-MCI.
Journal: Current Neurology and Neuroscience Reports - CURR NEUROL NEUROSCI REP , vol. 11, no. 4, pp. 371-378, 2011
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