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The paradox of α-adrenergic coronary vasoconstriction revisited

The paradox of α-adrenergic coronary vasoconstriction revisited,10.1016/j.yjmcc.2011.03.007,Journal of Molecular and Cellular Cardiology,Gerd Heusch

The paradox of α-adrenergic coronary vasoconstriction revisited   (Citations: 3)
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Activation of coronary vascular α-adrenoceptors results in vasoconstriction which competes with metabolic vasodilation during sympathetic activation. Epicardial conduit vessel constriction is largely mediated by α1-adrenoceptors; the constriction of the resistive microcirculation largely by α2-adrenoceptors, but also by α1-adrenoceptors. There is no firm evidence that α-adrenergic coronary vasoconstriction exerts a beneficial effect on transmural blood flow distribution. In fact, α-blockade in anesthetized and conscious dogs improves blood flow to all transmural layers, during normoperfusion and hypoperfusion. Also, in patients with coronary artery disease, blockade of α1- and α2-adrenoceptors improves coronary blood flow, myocardial function and metabolism.
Journal: Journal of Molecular and Cellular Cardiology - J MOL CELL CARDIOL , vol. 51, no. 1, pp. 16-23, 2011
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