U50,488H postconditioning reduces apoptosis after myocardial ischemia and reperfusion
Guang Tong, Zhongchan Sun, Xufeng Wei, Chunhu Gu, Alan David Kaye, Yuemin Wang, Juan Li, Quanyu Zhang, Haitao Guo, Shiqiang Yu, Dinghua Yi, Jianming Pei
AimsEvidence has indicated U50,488H, a selective κ-opioid receptor (κ-OR) agonist, administered before ischemia attenuates apoptosis and infarction during ischemia and reperfusion (I/R). However, it remains unclear whether U50,488H postconditioning reduces apoptosis during I/R. This study was designed, therefore, to test the hypothesis that U50,488H administered at the onset of reperfusion inhibits cardiomyocyte apoptosis and to investigate the underlying mechanisms.