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Toward new camptothecins. Part 7: Synthesis of thioluotonin and its 5-methoxycarbonyl derivative

Toward new camptothecins. Part 7: Synthesis of thioluotonin and its 5-methoxycarbonyl derivative,10.1016/j.tetlet.2011.01.105,Tetrahedron Letters,Thom

Toward new camptothecins. Part 7: Synthesis of thioluotonin and its 5-methoxycarbonyl derivative  
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The synthesis of thiodeoxyvasicinone and thioluotonin derivatives is described. The results obtained indicate that in these series, oxygen to sulfur replacement leads to absence of strong interaction with topoisomerase I-DNA.
Journal: Tetrahedron Letters - TETRAHEDRON LETT , vol. 52, no. 14, pp. 1592-1596, 2011
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