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Evaluation of Apoptosis in the Liver Preserved by Simple Hypothermia Using Histidine-Tryptophan-Ketoglutarate and Prolactin-Modified Histidine-Tryptophan-Ketoglutarate Solution

Evaluation of Apoptosis in the Liver Preserved by Simple Hypothermia Using Histidine-Tryptophan-Ketoglutarate and Prolactin-Modified Histidine-Tryptop

Evaluation of Apoptosis in the Liver Preserved by Simple Hypothermia Using Histidine-Tryptophan-Ketoglutarate and Prolactin-Modified Histidine-Tryptophan-Ketoglutarate Solution  
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IntroductionOrgan ischemia is accompanied by cell death due to apoptosis. It occurs together with necrosis, which has more unfavorable consequences due to the release of cytokines that activate the inflammatory response cascade. The aim of this study was to assess the degree of apoptosis in porcine livers preserved by simple hypothermia for 12 hours using standard solutions (University of Wisconsin [UW] and histidine-tryptophan-glutarate [HTK]), and to evaluate the effect of prolactin (PRL) addition to the HTK solution.
Journal: Transplantation Proceedings - TRANSPLANT PROC , vol. 43, no. 8, pp. 2900-2902, 2011
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