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Limited access ethanol drinking in the dark in adolescent and adult mice

Limited access ethanol drinking in the dark in adolescent and adult mice,10.1016/j.pbb.2011.01.003,Pharmacology Biochemistry and Behavior,Pamela Mette

Limited access ethanol drinking in the dark in adolescent and adult mice  
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Adult risk of alcohol dependence increases the younger one first engages in intoxicating consumption. Adolescent mice drink more ethanol than do adults on a gram per kilogram basis, an increase sometimes persisting into adulthood, and this is genotype-dependent. Most studies have used 24h two-bottle preference, with a choice between ethanol and water. We studied the developmental onset of binge drinking using limited access ethanol drinking in the dark (DID) in male and female mice. To establish age dependence in DID magnitude, we tested HS/Npt mice of 6 ages for DID for 2weeks, and when they were 9weeks old, we retested them for 2weeks vs naïve adult controls. Age groups drank equivalently in their first week; thus, adolescent HS/Npt mice do not show greater DID than adults. Six week old mice drank more ethanol during their second week relative to their other weeks. Ethanol DID during early adolescence (4weeks) led to increased drinking in adulthood, as did initial DID exposure at 8weeks. High drinking in the dark-1 (HDID-1) mice (4, 6, 9weeks old), selectively bred for high blood ethanol after DID, were tested for 9weeks. Mice beginning at 4weeks generally drank more ethanol than those of other age groups. Comparison at the same ages showed that 9week olds initiated at 4weeks drank more ethanol than did naïve 9week olds, but all three groups of age-matched mice drank equivalent amounts once they were 10weeks and older. The DID test is thus sensitive to developmental age. DID intakes by young adolescent HDID-1 mice were greater than intakes by older mice, like those shown by studies with two-bottle preference. Early DID led to increased drinking as adults only in HS/Npt mice. HDID-1 mice provide a useful animal model for exploring whether DID and continuous access preference drinking have parallel consequences when initiated in adolescence.
Journal: Pharmacology Biochemistry and Behavior - PHARMACOL BIOCHEM BEHAV , vol. 98, no. 2, pp. 279-285, 2011
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