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Chronic exposure to diclofenac on two freshwater cladocerans and Japanese medaka

Chronic exposure to diclofenac on two freshwater cladocerans and Japanese medaka,10.1016/j.ecoenv.2011.03.014,Ecotoxicology and Environmental Safety,J

Chronic exposure to diclofenac on two freshwater cladocerans and Japanese medaka   (Citations: 1)
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Consequences of long-term exposure to diclofenac up to 3 months were evaluated using freshwater crustaceans (Daphnia magna and Moina macrocopa) and a fish (Oryzias latipes). Marked decrease of reproduction was observed at 25mg/L for D. magna, and at 50mg/L for M. macrocopa. Three-month exposure of fish to 0.001–10mg/L of diclofenac resulted in significant decreasing trend in hatching success and delay in hatch. The hatching of the eggs produced from the fish exposed to 10mg/L was completely interfered, while fertility of the parent generation was not affected. Gonadosomatic index (GSI) of female fish was also affected at 10mg/L. Predicted no effect concentration of diclofenac was estimated at 0.1mg/L, which is a few orders of magnitude greater than those observed in ambient water. Therefore direct impact of diclofenac exposure is not expected. However its bioaccumulation potential through food web should warrant further evaluation.
Journal: Ecotoxicology and Environmental Safety - ECOTOXICOL ENVIRON SAFETY , vol. 74, no. 5, pp. 1216-1225, 2011
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